Effect of neuroserpin in a neonatal hypoxic-ischemic injury model ex vivo
نویسندگان
چکیده
منابع مشابه
A rat model of severe neonatal hypoxic-ischemic brain injury.
BACKGROUND AND PURPOSE Perinatal hypoxic-ischemic brain injury is a common problem with severe neurological sequelae. In this report we describe in detail a simple model of hypoxia-ischemia in the neonatal rat that gives rise to severe neocortical infarction and to selective hippocampal neuronal necrosis. METHODS Seven-day-old Simonsen Wistar rat pups underwent bilateral carotid artery ligati...
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PURPOSE To develop and compare an automated detection system for ischemic lesions in a neonatal model of bilateral carotid artery occlusion with hypoxia (BCAO-H) from T2 weighted MRI (T2WI) to the currently used "gold standard" of manual segmentation. MATERIALS AND METHODS Forty-three P10 BCAO-H rat pups and 8 controls underwent T2WI at 1 day and 28 days. A computational imaging method, Hiera...
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The objective of the present study was to evaluate the neuroprotective effects of immunoglobulin (Ig) in a neonatal hypoxic ischemic (HI) rat model. Seven-day-old rat pups were randomly assigned to control, hypoxia and hypoxia + Ig groups. The rats in the hypoxia +Ig group were intraperitoneally administered 1 g/kg Ig once, immediately after hypoxia. Saline was administered to the rats in the h...
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Hypoxic-ischemia (HI) causes severe brain injury in neonates. It's one of the leading causes to neonatal death and pediatric disability, resulting in devastating consequences, emotionally and economically, to their families. A series of events happens in this process, e.g. excitatory transmitter release, extracelluar Ca2+ influxing, mitochondrial dysfunction, energy failure, and neuron death. T...
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Immune cells display a high degree of phenotypic plasticity, which may facilitate their participation in both the progression and resolution of injury-induced inflammation. The purpose of this study was to investigate the temporal expression of genes associated with classical and alternative polarization phenotypes described for macrophages and to identify related cell populations in the brain ...
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ژورنال
عنوان ژورنال: Biological Research
سال: 2012
ISSN: 0716-9760
DOI: 10.4067/s0716-97602012000400005